Nanjing Anesthesia Medical Co., Ltd.
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The first-generation chlorhexidine–silver sulfadiazine (CSS) Hemodialysis Catheter reduce colonisation (odds ratio [OR] 0·51 [95% CI 0·42–0·61]) and CRBSI (OR 0·68 [0·47–0·98]), as do the minocycline–rifampicin hemodialysis catheter (OR 0·39 [0·27–0·55] and OR 0·29 [0·16–0·52], respectively). The minocycline–rifampicin hemodialysis catheter outperformed the first-generation CSS hemodialysis catheter in reducing colonisation (OR 0·34 [0·23–0·49]) and CRBSI (OR 0·18 [0·07–0·51]). Many shortcomings in methodological quality limit our interpretation of the study results. However, the available evidence suggests that use of CSS and minocycline–rifampicin hemodialysis catheter are useful if the incidence of CRBSI is above institutional goals despite full implementation of infection prevention interventions.
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